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چکیده
The ectodomain of Epidermal Growth Factor Receptor EGFR is a 100 KDa membrane glycoprotein and mediates the biological effects of polypeptide mitogens such as EGF and TGF-α, playing an important roles in the normal and pathological growth control. Overexpression has been observed in many types of human tumours [1] and therefore structure-based drug design for therapeutic modulation of receptor functions is of high medical interest. EGFR has been crystallised in the presence of ligand giving crystals of the space group P21212 with resolution of 4.5 Å [2].
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تاریخ انتشار 1999